Fast Dissolving Films A Novel Approach for Delivery of Domperidone, Book 1 (Paperback)

Fast Dissolving Films A Novel Approach for Delivery of Domperidone, Book 1 (Paperback) Describes the preparation and evaluation of orally fast dissolving film of Domperidone Focuses on overcoming the challenge of Domperidone's low water solubility Utilizes solid dispersion approach with beta-cyclodextrin as a carrier Solid dispersions prepared in various molar ratios of Drug: Carrier Optimized solid dispersion selected for film preparation Suitable film forming polymer selected from HPMC E3 LV, HPMC E5 LV, HPMC E15 LV, and pullulan Pullulan found to be the most suitable polymer for film preparation Films prepared using pullulan and PEG-400 by solvent casting method Evaluated using factorial design to determine optimized formulation Results indicate films made with solid dispersion outperform those made with plain Domperidone